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Semaglutide 5mg/vial,10vials/kit, Wegovy ,Ozempic Brand

Wegovy ,Ozempic Semaglutide is a derivative of the naturally occurring GLP-1, a peptide known to lower blood sugar levels and enhance insulin secretion. Research shows that Semaglutide may also improve heart, liver, and lung function while helping to slow
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Semaglutide and GLP-1 Overview

Wegovy ,Ozempic Brand Semaglutide 5mg&10mg&30mg...
 

GLP-1, short for glucagon-like peptide-1 is a short, naturally occurring peptide hormone just 30-31 amino acids in length. Its primary physiologic function is to lower blood sugar levels by naturally enhancing insulin secretion. It also plays roles in protection beta cell insulin stores by promoting insulin gene transcription and has been linked with neurotrophic effects in the brain and central nervous system. In the GI system, GLP-1 has been shown to significantly decrease appetite by delaying gastric emptying and reducing intestinal motility. Preliminary research has shown impacts of GLP-1 in the heart, fat, muscles, bones, liver, lungs, and kidneys as well.

The primary focus of GLP-1 research has been in the realm of diabetes treatment/prevention as well as appetite suppression. Secondary research focuses on the potential cardiovascular benefits of the peptide. More recent, and thus less robust, research focuses on the ability of GLP-1 to stave off neurodegenerative disease. Though this latter area of research is newest, it is also the fast-growing area of GLP-1 study now that the peptide has been revealed to slow or prevent the accumulation of amyloid beta plaques in the setting of Alzheimer’s disease.

Semaglutide Structure

GLP-1 Structure

Sequence: HXEGTFTSDVSSYLEGQAAK-OH.steric diacid-EFIAWLVRGRG
Molecular Formula: C187H291N45O59
Molecular Weight: 4113.64 g/mol
PubChem CID: 56843331
CAS Number: 910463-68-2
Synonyms: Semaglutide, Oxempic, Rybelsus, NN9535

Semaglutide and GLP-1 Research

The Incretin Effect of GLP-1

Perhaps the most important effect that GLP-1 has, according to Dr. Holst, is referred to as the “incretin effect.” Incretins are a group of metabolic hormones, released by the GI tract, that cause a decrease in blood glucose (sugar) levels. GLP-1 has been shown to be one of the two most important hormones (the other being GIP) to stimulate the incretin effect in rodent models. Though GIP circulates at levels roughly 10 times higher than that of GLP-1, there is evidence that GLP-1 is the more potent of the two molecules, particularly when levels of blood glucose are quite high.

A GLP-1 receptor has been identified on the surface of pancreatic beta cells, making it clear that GLP-1 directly stimulates the exocytosis of insulin from the pancreas. When combined with sulfonylurea drugs, GLP-1 has been shown to boost insulin secretion enough to cause mild hypoglycemia in up to 40% of subjects[1]. Of course, increased insulin secretion is associated with a number of trophic effects including increased protein synthesis, reduction in the breakdown of protein, and increased uptake of amino acids by skeletal muscle.

GLP-1 and Beta Cell Protection

Research in animal models suggests that GLP-1 can stimulate the growth and proliferation of pancreatic beta cells and that it may stimulate the differentiation of new beta cells form progenitors in the pancreatic duct epithelium. Research has also shown that GLP-1 inhibits beta cell apoptosis[1]. Taken in sum, these effects tip the usual balance of beta cell growth and death toward growth, suggesting that the peptide may be useful in treating diabetes and in protecting the pancreas against insult that harms beta cells.

In one particularly compelling trial, GLP-1 was shown to inhibit the death of beta cells caused by enhanced levels of inflammatory cytokines. In fact, mouse models of type 1 diabetes have revealed that GLP-1 protects islet cells from destruction and may, in fact, be a useful means of preventing onset of the type 1 diabetes[2].

GLP-1 and Appetite

Research in mouse models suggests that administration of GLP-1, and its similar cousin GLP-1, into the brains of mice can reduce the drive to eat and inhibit food intake[3]. It appears that GLP-1 may actually enhance feelings of satiety, helping individuals to feel fuller and reducing hunger indirectly. Recent clinical studies have shown in mice that twice daily administration of GLP-1 receptor agonists cause gradual, linear weight loss. Over a long period, this weight loss is associated with significant improvement in cardiovascular risk factors and a reduction in hemoglobin A1C levels, the latter of these being a proxy marker for the severity of diabetes and the quality of blood sugar control attained via treatment[4].

Potential Cardiovascular Benefits of GLP-1

It is now know that GLP-1 receptors are distributed throughout the heart and act to improve cardiac function in certain settings by boosting heart rate and reducing left ventricular end-diastolic pressure[5]. The latter may not seem like much, but increased LV end-diastolic pressure is associated with LV hypertrophy, cardiac remodeling, and eventual heart failure.

Recent evidence has even suggested that GLP-1 could play role in decreasing the overall damaged caused by a heart attack. It appears that the peptide improves cardiac muscle glucose uptake, thereby helping struggling ischemic heart muscle cells to get the nutrition they need to continue functioning and avoid programmed cell death. The increase in glucose uptake in these cells appears to independent of insulin[6].

Large infusions of GLP-1 into dogs have been shown to improve LV performance and reduce systemic vascular resistance. The latter effect can help to reduce blood pressure and ease strain on the heart as a result[7]. This, in turn, can help to reduce the long-term consequences of high blood pressure such as LV remodeling, vascular thickening, and heart failure. According to Dr. Holst, administration of GLP-1 following cardiac injury has “constantly increased myocardial performance both in experimental animal models and in patients.”

Size of damage in heart in control mice (A), mice given standard vasopressin therapy (B), and mice give GLP-1 (C).

Size of damage in heart in control mice (A), mice given standard vasopressin therapy (B), and mice give GLP-1 (C).

GLP-1 and the Brain

There is some evidence to suggest that GLP-1 can improve learning and help to protect neurons against neurodegenerative diseases such as Alzheimer’s disease. In one study, GLP-1 was shown to enhance associative and spatial learning in mice and even to improve learning deficits in mice with specific gene defects. In rats that over-express the GLP-1 receptor in certain regions of the brain, learning and memory are both significantly better than in their normal controls[8].

Additional research in mice has shown that GLP-1 can help to protect against excitotoxic neuron damage, completely protecting rat models of neurodegeneration against glutamate-induced apoptosis. The peptide can even stimulate neurite outgrowth in cultured cells. Researchers are hopeful that additional research on GLP-1 will reveal how it might be used to halt or reverse certain neurodegenerative diseases[9].

 

Recommended Dosage

Generally, the doctor will start a low dose of semaglutide injection for the patient, and gradually increase it after 4 weeks. The dosage may be increased again after the succeeding 4 weeks depending on the patient’s response to the medication. This will go on until the maintenance dose of 2.4 mg/week is reached. The table below is an example of the standard dosing schedule for a semaglutide injection.

1st Month 0.25 mg/week
2nd Month 0.5 mg/week
3rd Month 1 mg/week
4th Month 1.7 mg/week
5th Month and beyond 2.4 mg/week (maintenance dose)

Administer the semaglutide injection only as prescribed by the doctor and exactly as directed, neither more nor less than the dosage and schedule.

 

How Much Sterile/Bacteriostatic Water to Mix with 5mg of Semaglutide ?

 

Mixing medications correctly is crucial for ensuring their efficacy and safety. Semaglutide, a medication used primarily in the treatment of type 2 diabetes, often comes in a powdered form that requires reconstitution with a diluent like bacteriostatic water. This article will explore the appropriate methods and quantities for mixing bacteriostatic water with 5mg of semaglutide.

How to Determine the Correct Amount of Bacteriostatic Water for Semaglutide?

The correct amount of bacteriostatic water to be mixed with semaglutide is determined by the concentration needed for the medication. Typically, the manufacturer provides specific instructions regarding the reconstitution process. For a 5mg dose of semaglutide, the amount of bacteriostatic water required can vary based on the desired concentration. It’s essential to refer to the product’s instruction leaflet or consult with a healthcare professional for precise measurements.

Without specific instructions from a product’s prescribing information or guidance from a healthcare provider, giving a specific mixing ratio would be irresponsible. However, a general example can be provided to illustrate how to calculate the mixing ratio.

Suppose there is 5mg of Semaglutide and the goal is to prepare a solution where each 1ml contains 1mg of Semaglutide. The following steps would be followed to calculate the amount of bacteriostatic water needed:

  • Determine the target concentration: 1mg/ml.
  • Identify the total amount of drug: 5mg.
  • Calculate the total amount of solvent (in this example, bacteriostatic water) needed to dissolve 5mg of Semaglutide to achieve a concentration of 1mg/ml.
  • Thus, to achieve a concentration of 1mg/ml, 4ml of bacteriostatic water would need to be added to the 5mg of Semaglutide. This would result in a final volume of 5ml, with a concentration of 1mg/ml.

Please note, this is just an example, and actual practice should follow the guidance provided in the drug’s prescribing information or from a healthcare professional. Different target concentrations and dosing requirements will result in different proportions. It is always important to follow the correct guidance to ensure the safety and efficacy of the medication.

Where Should the Mixing Process Take Place?

The mixing of semaglutide with bacteriostatic water should occur in a clean and controlled environment to prevent contamination. This process is typically performed in a clinical setting or at home, following strict hygiene practices. It’s important to use sterile equipment and ensure that the area where the mixing takes place is free from potential contaminants.

Why Is It Important to Use Bacteriostatic Water?

Bacteriostatic water is used as a diluent for semaglutide because it inhibits the growth of bacteria, ensuring that the reconstituted medication remains sterile for a longer period. This is particularly important for medications that do not contain preservatives. Using bacteriostatic water helps maintain the integrity of the medication and ensures its safety for use.

Conclusion

Mixing semaglutide with the correct amount of bacteriostatic water is a critical step in its preparation for use. Following the manufacturer’s guidelines and consulting with healthcare professionals can ensure accurate dosing and medication efficacy. The importance of using bacteriostatic water lies in its ability to maintain the sterility of the medication, emphasizing the need for proper handling and preparation techniques.

References

  1. Semaglutide medication information: FDA
  2. Guidelines for reconstitution of medications: Pharmacy Times
  3. Importance of sterile compounding practices: American Pharmacists Association
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