N-Acetyl Selank Amidate 10mg

N-Acetyl Selank Amidate

N-Acetyl Selank Amidate is best thought of as an enhanced version of Selank. Research has shown that N-Acetyl Selank Amidate improves on every aspect of Selank by increasing its potency, half-life, absorbability, and the ease with which it crosses the blood-brain barrier. These features help to enhance the effects of Selank, which has been found in animal studies to protect the central nervous system from disease and trauma, reduce anxiety, improve learning, improve memory, and alter the process of blood clotting. While more research remains to be done, Selank and other glyprolines offer an foresight, into how DNA expression patterns can be altered by a single peptide to produce dramatic effects.

N-Acetyl Selank Amidate

N-Acetyl Selank Amidate is a modified form of the peptide Selank. Selank is a short nootropic and anxiolytic peptide originally developed in Russia. It is an analogue of naturally occurring tuftsin and has been shown to have immunomodulatory effects. Research suggests that Selank modifies gene expression in the brain, reducing the effects of the neurotransmitter GABA, altering cell membrane permeability, and enhancing production of brain-derived neurotrophic factor (BDNF).

The modified form of Selank, N-Acetyl Selank Amidate has a longer half-life and greater ability to cross the blood-brain barrier. It also has tighter receptor binding due to the amidation. Selank is currently being researched in animal models for the treatment of stroke and other ischemic brain diseases. It is also under consideration as a treatment of generalized anxiety disorder and to protect memory in the setting of neurodegenerative disease.

N-Acetyl Selank Amidate Structure

Amino Acid Sequence:Ac-TPRKEPV-NH2
Molecular Formula: C₃₃H₅₇N₁₁O₉
Molecular Weight: 751.9 g/mol
PubChem CID: 11765600
CAS Number: 129954-34-3
Synonyms: Selanc, TP-7, UNII – TS9JR8EP1G

Here in the sequence, "Ac-" represents the Acetyl group attached to the N-terminus of the peptide, and "-NH2" represents the Amidated group at the C-terminus. The amino acid sequence "TPRKEPV" corresponds to the core Selank peptide. Acetyl-Selank-Amidate is a modified version of Selank, a synthetic peptide with anxiolytic and immunomodulatory properties. The addition of the Acetyl and Amidated groups may enhance its stability, bioavailability, and efficacy.

N-Acetyl Selank Amidate and DNA

Selank has several effects, particularly in the central nervous system, that are of interest to scientists. Research from Dr. Anastasiya Volkova (Institute of Molecular Genetics, Russia) indicates that Selank produces these effects because of modulating gene expression. In other words, Selank can turn on or off parts of DNA to affect the function of our bodies. Research in rats shows that Selank modifies the function of at least 52 different genes[1].

Selank and Anxiety

Perhaps the most carefully and thoroughly studied property of Selank is its ability to modulate anxiety. Research shows that Selank has clinical effects that are like those of drugs like benzodiazepines used in the treatment of serious anxiety disorders. Selank has been shown to effectively reduce anxiety, lower stress, and improve mood. It appears to do so via interaction (probably indirect) with the GABA_A receptor, just as benzodiazepines do. It even has similar sedative effects when compared to benzodiazepines.