Melanostatin definition: a peptide that inhibits the release of melanotropin. Melanostatin-DM is a synthetic version of Melanostatin, a molecule derived from oxytocin, the well-known happy hormone.
Melanostatin comprises of only three amino acids and has the ability to block the effects of the opioid receptor, thus triggering dopamine receptors and inhibiting the release of α-MSH neuropeptide. Owing to its extended amino acid sequence and structure, the Melanostatin hormone can only affect α-MSH signaling in animal models.
According to scientific research, Melanostatin DM functions as a skin-whitening agent and brightener. Studies on animals suggest Melanostatin treatment can interfere with the synthesis of melanin to lighten the skin tone and lessen pigmentation and discoloration.
Studies performed on animal models indicate that Melanostatin DM peptide antagonizes melanocyte-stimulating hormone, a hormone that instructs pigment cells, or melanocytes, to produce melanin. This hormone tends to increase in mice during pregnancy. It’s usually triggered by sun exposure and certain diseases such as diabetes.
Research shows that Melanostatin’s interference with melanocyte-stimulating hormone effects can prevent the activation of the tyrosinase enzyme. Tyrosinase is an enzyme[ii] responsible for the first step in melanin production. It converts tyrosine into another compound known as dihydroxyphenylalanine (DOPA), which causes skin darkening. Melanostatine prevents the production of melanin, thereby preventing and reversing skin darkening.
The research so far is compelling. With further research, we hope to gain a deeper understanding of this intriguing topical peptide.
There are various ways to lighten the skin in animal test subjects. According to experts, the best way to lighten skin is by inhibiting tyrosinase activity. Doing this reduces the synthesis of melanin so that existing skin cells undergo gentle exfoliation with less melanin, revealing lighter, more even-toned skin.
Tyrosinase is the primary enzyme in the formation of melanin. By lessening its activity, one can experience improved skin tone and a lighter complexion as tests in animal test subjects have shown. The way to achieve this is by blocking the production of tyrosinase, inhibiting its activity, and preventing it from darkening the skin.
While you won’t currently find it in most cosmetics, researchers believe it will not be long before you can purchase it as an over-the-counter treatment. The research thus far is indeed promising.
Animal studies and testing in lab-grown mice skin cells indicate that Melanostatin peptide can significantly reduce melanin production in melanocytes. Research shows that the compound can inhibit approximately 25% of melanin production. This goes to show that this topical skincare treatment is indeed effective in lightening skin and improving skin tone as research on animals has shown.
Hyperpigmentation is a common dermatologic issue that arises from an overproduction of melanin, the skin’s main pigment. With excessive sun exposure and hormonal fluctuations, melanocytes become hyperactive and release too much melanin, resulting in dark patches on the skin. Heredity also plays a role in abnormal melanin output, leading to pigmentation disorders such as melasma.
Melanostatin DM significantly lessens the production of melanin and prevents hyperactivity from occurring. As a result, it’s an effective treatment for pigmentation issues as tests in animal test subjects have shown.
Researchers generally consider the topical use of Melanostatin as safe. Like with all ingredients, there is always a risk of certain potential effects. In such cases, these may include skin irritation, redness, rash, or a temporary burning sensation of the skin as research on animals has shown.
At present, Melanostatin is not yet approved by the FDA. That said, research thus far hasn’t shown any severely negative side effects of Melanostatin when used topically in research studies.
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